Development and evaluation of acyclovir loaded chitosan microspheres and cross linked with glutaraldehyde
نویسندگان
چکیده
The guanine derivative antiviral drug acyclovir (ACV) is one of the oldest molecules put downing triumphant market until date, being commercially accessible in a variety dosage forms for oral, topical and parenteral administrations. Clinical purpose this better to new agents due its potential values such as suppression recurrence, security profile, negligible interactions inexpensive. ACV slightly water soluble, less permeable poorly bioavailable, yet further molecule, physicochemical alterations form approaches resulted with more than 100 research efforts within decade. current study endeavored at formulation chitosan microspheres loaded conquer poor bioavailability recurrent dose administration. Chitosan were prepared by emulsification technique glutaraldehyde cross-linking. A process variables polymer, glutaraldehyde, drug, span 80 concentrations, effect stirring speed time optimized. Formulated characterized loading, invitro release, entrapment efficiency, surface morphology (SEM), particle size analysis FTIR spectroscopy. characterization fabricated demonstrated smooth thin allocation efficiency 80.8% batch. showed controlled release 93.2% over period 8 hrs initial burst 56.7 % first 2hrs. that there was no possible interaction among polymer. From data’s obtained it can be concluded could believed carrier delivery ACV.
 Keywords: Acyclovir, Antiviral Microspheres, Chitosan, Glutaraldehyde.
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ژورنال
عنوان ژورنال: Journal of Drug Delivery and Therapeutics
سال: 2021
ISSN: ['2250-1177']
DOI: https://doi.org/10.22270/jddt.v11i5.5123